Distinguishing between demon possession and psychological disorders involves understanding both spiritual and mental health perspectives. In the Bible, individuals like King Saul and the demon-possessed man of Gerasenes exhibited symptoms that can be interpreted through both lenses, showing how mental distress may manifest alongside spiritual influences or have similar features (1 Samuel 16:14; Mark 5:1–20). Psychological disorders should be carefully evaluated and treated with appropriate medical and mental health interventions, yet we should also address the physical and spiritual components. It’s essential to consider the individual’s spiritual beliefs, as a hardened heart (Hebrews 3:13) or involvement in idolatry (1 Corinthians 10:14) may open someone to spiritual oppression. Ultimately, effective support should include prayer, practical treatment, and a compassionate approach to both psychological and spiritual needs.
Rarely is distress limited to one aspect of a person’s life. For example, physical illness can lead to mental anguish and spiritual gloom. Spiritual darkness can result in mental instability. Regardless of whether a person's disorder is primarily psychological, physical, spiritual, or an obvious combination of the three, we must look at and address all three. This includes praying for salvation, praying for improved health, and praying against any spiritual forces of evil that may be present. It includes doing something about all three as well. A person exhibiting psychological symptoms should be evaluated for mental health disorders. If something physical or mental is detected, then these issues should be treated appropriately. There is no reason to deny medical or mental health treatment to someone because of perceived demonic influences. Physical symptoms must also be addressed. Perhaps the person is deficient in some nutrient or vitamin. Perhaps they have an illness or are on a medication that is causing these psychological manifestations. We must also consider the spiritual beliefs and situation of the person. An unbeliever can open themselves up to demonic possession through idolatry or hardening one’s heart as well as cult involvement, drug and alcohol abuse, sin and immorality, rebellion, bitterness, and new age practices, including transcendental meditation or astral projection. The Bible indicates a person who is truly a Christian cannot be possessed by a demon (2 Corinthians 1:22). If a person is a Christian, then he or she is not possessed but may have other spiritual concerns that need to be addressed.
It is clear God wants us to pray for those in trouble, regardless of what kind. We are also called to responsibly diagnose and treat psychological and medical concerns whenever possible. Through both practical actions and spiritual prayer and concern, we can better help those who struggle with mental or spiritual problems.