Despair is best understood as a complete absence of hope. Often a sense of helplessness is also associated with despair. Temptation to despair is fairly common; we live in a fallen world with no shortage of things that try to crush our hope. When we despair, we reject the truth of what Jesus has done for us. Instead, we need to hold on to the hope of Christ.
In the midst of despair, it can be hard to change your mindset. In addition to the Scriptures quoted above, there are some other biblical truths that we can grab hold of when we are tempted to despair:
"When the righteous cry for help, the LORD hears and delivers them out of all their troubles. The LORD is near to the brokenhearted and saves the crushed in spirit. Many are the afflictions of the righteous, but the LORD delivers him out of them all" (Psalm 34:17–19).
"Humble yourselves, therefore, under the mighty hand of God so that at the proper time he may exalt you, casting all your anxieties on him, because he cares for you" (1 Peter 5:6–7).
"When I thought, 'My foot slips,' your steadfast love, O LORD, held me up. When the cares of my heart are many, your consolations cheer my soul" (Psalm 94:18–19).
You might be in a place where you are currently struggling to have hope. Remind yourself that, like it was for Paul, you are going through a season that will eventually pass. You will again be in a place where joy and praise come easily, and there are things for which you can be grateful, even now (Ecclesiastes 3:1–13). If you are struggling with falling into despair, surround yourself with the truth of God's Word and remind yourself of God's promises. Don't be afraid or ashamed to share this struggle with a mature believer, who might be able to help you through this time and remind of you the truth that you are struggling to believe. Despair can lead us to isolate ourselves, but the family of God can encourage us and walk alongside us in difficult times, so refuse to believe the lie that you must suffer alone (Romans 12:15). If you struggle with depression, you should consider seeing a Christian counselor and getting whatever medical help you might need. Oftentimes, when tempted by despair, the most we can do is have the attitude displayed in Psalm 43:5, "Why are you cast down, O my soul, and why are you in turmoil within me? Hope in God; for I shall again praise him, my salvation and my God."